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S4 (Andarine) or Acetamidoxolutamide, is a SARM (Selective Androgen Receptor Modulator). S4 is said to be the most potent SARM which helps sustain lean muscle mass while stimulating fat elimination at the same time.

What is S4?

To start, let’s describe what a SARM does. There are three type of chemicals that act on the androgen receptor (AR). One is the an AR antagonist, which is a chemical that binds to the receptor to prevent it from activating. The second is an AR agonist, which binds to the receptor and detaches, then binds again, over and over. An example of an AR agonist is testosterone, each time the AR is bonded with testosterone, a signal is sent out to activate a particular set of genes. The more testosterone that is in the system, the more AR binding will occur. The third is an AR modulator, or basically a molecule that attaches to an AR and changes its structure to react however it wants.

How S4 Andarine Works:

S4 binds to the AR in muscle and bone at a third of the affinity as testosterone.
SARMS themselves bind to the AR (androgen receptor) and demonstrate osteo (bone) and myo (muscular) anabolic activity. When something binds and activates the AR it alters the expression of genes and increases protein synthesis which as a result builds muscle. SARMS cause muscle growth in the same method as steroids however the difference is that SARMS do not enhance the growth of ones prostate and affect other sexual organs. They do not cause the many problems that anabolics can cause, they don’t have the toxicity and in some circumstances only cause minimal suppression which allows for a rapid recovery. Steroids can cause long term problems from the high rates of suppression and unlike SARMS, they can actually reduce the sense of well being each day.

Strength Gains and Lean Mass Gains

Lean mass powder S4 provides huge amounts of strength, stamina and aides in rapid recovery. There is no estrogen conversion, no water retention or bloat and no toxicity. Thanks to its anabolic nature, the strength gains come rapidly but lean mass gains is the primary target from use.

Dosing Guidelines

S-4 should be taken at 50mg-75mg, 5 days out of the week, for 12-16 weeks. As mentioned before, S-4 does not need to be taken on 3 separate occasions throughout the day; but for individuals that prefer this method, a 25mg dose (roughly half a milliliter) is recommended once with each of your three main meals.

Once again, as mentioned above, S-4 does have point of diminishing returns. This means usage of S-4 passed 75mg or usage of S-4 for more than 16 weeks will not result in any added muscle mass. There will not be an increase in side effects either, but you will be running the risk of AR desensitization and inevitably wasting your product.

Dosing with S-4 for less than 6-8 weeks is not recommended and will not allow the researcher to witness the full benefits of the product.

Recommended dose for cutting is 50 mg for 6-8 weeks. You should use it every day then take 2 days off for the duration. Taking S4 daily for the length of the cycle can lead to changes in eyesight.